Tumor-to-tumor metastasis to the central nervous system.
نویسندگان
چکیده
Tumor-to-tumor metastasis is a well-recognized phenomenon. Meningioma is the most common intracranial host tumor, with the breast and lung being the most common primary sites. We report herein two such cases of metastasis from pulmonary adenocarcinoma and malignant melanoma (MM) of vulva, respectively. Case 1: a 69-year-old female smoker who had a history of right upper lobectomy of lung for adenocarcinoma presented with a headache and altered mental status, and was found to have a left temporal contrast-enhancing mass with massive surrounding edema on MRI. The resection specimen revealed foci of metastatic adenocarcinoma within a microcystic meningioma. Case 2: a 75-year-old woman with a history of radical vulvectomy for MM died of widespread systemic metastasis of MM. At autopsy, a 2.5 x 2 x 2 cm firm nodule attached to the falx was incidentally found, with focal black discoloration at the periphery of the mass. Histologic examination showed a fibroblastic meningioma with a focus of metastatic MM. Case 1 is the first case report describing a microcystic variant of meningioma harboring metastatic carcinoma. Although MM is one of the most common metastatic brain tumors, MM-to-meningioma metastasis is reportedly extremely rare, but can occur.
منابع مشابه
Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis
Objective(s): This study aimed to explore the contribution of tumor necrosis factor (TNF) in the recruitment of B-cell and secretion of immunoglobulins (Igs) during cerebral tuberculosis (TB).Materials and Methods: In this work, the contributing role of TNF in regulating Ig secretions was investigated by comparing wild type TNF (TNFf/f),...
متن کاملMalignant Meningioma with Lumbar Spinal Metastasis (a case report)
Meningioma is considered as a benign central nervous system tumor that accounts for approximately 18% of all brain tumors. About 5% of meningioma tumors are malignant and have more aggressive clinical signs and worse prognosis compared to benign tumors. Extracranial metastasis of meningioma is rare but in the case of occurrence, it is more prevalent in lung, liver and lymph nodes. Osseous metas...
متن کاملCushing’s syndrome associated with typical, peripheral pulmonary carcinoid tumor and N2 lymph node metastasis: case report
Background: The bronchopulmonary carcinoid tumor accounts for 1-2% of all adult malignancies of the lung and 20-30% of all carcinoid tumors. Cushing’s syndrome is the result of chronic exposure to increased concentration of exogenous or endo-genus cortisol hormone, and it is generally associated with central obesity, metabolic syndrome, and hypertension. Treatment is based on decreasing cortiso...
متن کاملبررسی عوامل خطر درگیری میکروسکوپی غدد لنفاوی مرکزی گردن در بیماران مبتلا به کانسر پاپیلاری تیروئید بدون درگیری واضح غدد لنفاوی گردنی
Background: Despite the long-term survival in papillary thyroid cancer (PTC), cervical lymph node metastasis is the most important factor in regional recurrence of the disease. The aim of the present study was to find clinical risk factors for microscopic metastasis to the lymph nodes, without involvement of the neck lymph nodes. Methods: medical records of 115 PTC patients who underwent tot...
متن کاملAn overview of therapeutic approaches to brain tumor stem cells
Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radi...
متن کاملEpidemiological features of Central Nervous System tumors at MAHAK Pediatric Cancer Treatment and Research Center
Background: In this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to MAHAK Pediatric Cancer Treatment and Research Center (one of the main national referral centers for childhood malignancies in Iran) for treatment. Materials and Methods: This cohort (simple sampling) study consisted of 198 children less than 15 year old with CNS tumor ref...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuropathology : official journal of the Japanese Society of Neuropathology
دوره 29 3 شماره
صفحات -
تاریخ انتشار 2009